Macrophage membrane (MMs) camouflaged near-infrared (NIR) responsive bone defect area targeting nanocarrier delivery system (BTNDS) for rapid repair: promoting osteogenesis via phototherapy and modulating immunity.

ABSTRACT: Bone defects remain a significant challenge in clinical orthopedics, but no targeted medication can solve these problems. Inspired by inflammatory targeting properties of macrophages, inflammatory microenvironment of bone defects was exploited to develop a multifunctional nanocarrier capable of targeting bone defects and promoting bone regeneration. The avidin-modified black phosphorus nanosheets (BP-Avidin, BP_Avi) were combined with biotin-modified Icaritin (ICT-Biotin, ICT_Bio) to synthesize Icaritin (ICT)-loaded black phosphorus nanosheets (BP_ICT). BP_ICT was then coated with macrophage membranes (MMs) to obtain MMs-camouflaged BP_ICT (M@BP_ICT). Herein, MMs allowed BP_ICT to target bone defects area, and BP_ICT

SUBMITTER: Xue P 

PROVIDER: S-EPMC10908146 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature