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Macrophage membrane (MMs) camouflaged near-infrared (NIR) responsive bone defect area targeting nanocarrier delivery system (BTNDS) for rapid repair: promoting osteogenesis via phototherapy and modulating immunity.

ABSTRACT: Bone defects remain a significant challenge in clinical orthopedics, but no targeted medication can solve these problems. Inspired by inflammatory targeting properties of macrophages, inflammatory microenvironment of bone defects was exploited to develop a multifunctional nanocarrier capable of targeting bone defects and promoting bone regeneration. The avidin-modified black phosphorus nanosheets (BP-Avidin, BP_Avi) were combined with biotin-modified Icaritin (ICT-Biotin, ICT_Bio) to synthesize Icaritin (ICT)-loaded black phosphorus nanosheets (BP_ICT). BP_ICT was then coated with macrophage membranes (MMs) to obtain MMs-camouflaged BP_ICT (M@BP_ICT). Herein, MMs allowed BP_ICT to target bone defects area, and BP_ICT accelerated the release of phosphate ions (PO₄^3-) and ICT when exposed to NIR irradiation. PO₄^3- recruited calcium ions (Ca²⁺) from the microenvironment to produce Ca₃(PO₄)₂, and ICT increased the expression of osteogenesis-related proteins. Additionally, M@BP_ICT can decrease M1 polarization of macrophage and expression of pro-inflammatory factors to promote osteogenesis. According to the results, M@BP_ICT provided bone growth factor and bone repair material, modulated inflammatory microenvironment, and activated osteogenesis-related signaling pathways to promote bone regeneration. PTT could significantly enhance these effects. This strategy not only offers a solution to the challenging problem of drug-targeted delivery in bone defects but also expands the biomedical applications of MMs-camouflaged nanocarriers.

SUBMITTER: Xue P

PROVIDER: S-EPMC10908146 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature

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Macrophage membrane (MMs) camouflaged near-infrared (NIR) responsive bone defect area targeting nanocarrier delivery system (BTNDS) for rapid repair: promoting osteogenesis via phototherapy and modulating immunity.

Xue Peng P Chang Zhiyong Z Chen Hao H Xi Hongzhong H Tan Xiaoxue X He Shuai S Qiao Haishi H Jiang Xiaohong X Liu Xin X Du Bin B

Journal of nanobiotechnology 20240301 1

Bone defects remain a significant challenge in clinical orthopedics, but no targeted medication can solve these problems. Inspired by inflammatory targeting properties of macrophages, inflammatory microenvironment of bone defects was exploited to develop a multifunctional nanocarrier capable of targeting bone defects and promoting bone regeneration. The avidin-modified black phosphorus nanosheets (BP-Avidin, BP<sub>Avi</sub>) were combined with biotin-modified Icaritin (ICT-Biotin, ICT<sub>Bio</ ...[more]

PMID: 38429776

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Dataset Information

Macrophage membrane (MMs) camouflaged near-infrared (NIR) responsive bone defect area targeting nanocarrier delivery system (BTNDS) for rapid repair: promoting osteogenesis via phototherapy and modulating immunity.

Publications

Macrophage membrane (MMs) camouflaged near-infrared (NIR) responsive bone defect area targeting nanocarrier delivery system (BTNDS) for rapid repair: promoting osteogenesis via phototherapy and modulating immunity.

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