Diagnostic value of plasma-derived exosomal miR-223 for epithelial ovarian cancer.

ABSTRACT:

Objectives

To evaluate the diagnostic value of plasma exosomal miR-223 and its combination with CA125 for the diagnosis of early-stage epithelial ovarian cancer (EOC).

Patients and methods

Exosomes derived from the plasma of 78 EOC patients, 40 patients with epithelial benign ovarian tumors, and 52 healthy participants were isolated using the ultracentrifugation method and identified by transmission electron microscopy (TEM) and western blot.

Results

The expression of exosomal miR-223 was significantly upregulated in the plasma of EOC patients compared to that in healthy subjects and patients with benign diseases. The combination of exosomal miR-223 and CA125 from plasma had an equivalent area under the ROC curve (AUC) to CA125 alone for discriminating between EOC and

SUBMITTER: Yang L 

PROVIDER: S-EPMC10908149 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature