Multi-omics data elucidate parasite-host-microbiota interactions and resistance to Haemonchus contortus in sheep.

ABSTRACT:

Background

The integration of molecular data from hosts, parasites, and microbiota can enhance our understanding of the complex biological interactions underlying the resistance of hosts to parasites. Haemonchus contortus, the predominant sheep gastrointestinal parasite species in the tropics, causes significant production and economic losses, which are further compounded by the diminishing efficiency of chemical control owing to anthelmintic resistance. Knowledge of how the host responds to infection and how the parasite, in combination with microbiota, modulates host immunity can guide selection decisions to breed animals with improved parasite resistance. This understanding will help refine management practices and advance the development of new therapeutics for long-term helmin

SUBMITTER: Niciura SCM 

PROVIDER: S-EPMC10908167 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature