Oct4 activates IL-17A to orchestrate M2 macrophage polarization and cervical cancer metastasis.

ABSTRACT:

Background

Cervical cancer is a common malignant tumor in the female. Interleukin (IL)-17A is a proinflammatory factor and exerts a vital function in inflammatory diseases and cancers. M2 macrophage has been confirmed to promote tumor development. Nevertheless, it is not yet known whether IL-17A facilitates cervical cancer development by inducing M2 macrophage polarization. Therefore, this study was conducted to investigate the regulatory effect of IL-17A on M2 macrophage polarization and the underlying mechanism in cervical cancer development.

Methods

RT-qPCR was utilized for testing IL-17A expression in cancer tissues and cells. Flow cytometry was applied to evaluate the M1 or M2 macrophage polarization. Cell proliferative, migratory, and invasive capabilities were measure

SUBMITTER: Bian Z 

PROVIDER: S-EPMC10908604 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature