Loss of miR-101-3p in melanoma stabilizes genomic integrity, leading to cell death prevention.

ABSTRACT: Malignant melanoma remains the most lethal form of skin cancer, exhibiting poor prognosis after forming distant metastasis. Owing to their potential tumor-suppressive properties by regulating oncogenes and tumor suppressor genes, microRNAs are important player in melanoma development and progression. We defined the loss of miR-101-3p expression in melanoma cells compared with melanocytes and melanoblast-related cells as an early event in tumor development and aimed to understand the tumor suppressive role of miR-101-3p and its regulation of important cellular processes. Reexpression of miR-101-3p resulted in inhibition of proliferation, increase in DNA damage, and induction of apoptosis. We further determined the nuclear structure protein Lamin B1, which influences nuclear processes and he

SUBMITTER: Lammerhirt L 

PROVIDER: S-EPMC10909299 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature