Effects of bariatric surgery and dietary interventions for obesity on brain neurotransmitter systems and metabolism: A systematic review of positron emission tomography (PET) and single-photon emission computed tomography (SPECT) studies.

ABSTRACT: This systematic review collates studies of dietary or bariatric surgery interventions for obesity using positron emission tomography and single-photon emission computed tomography. Of 604 publications identified, 22 met inclusion criteria. Twelve studies assessed bariatric surgery (seven gastric bypass, five gastric bypass/sleeve gastrectomy), and ten dietary interventions (six low-calorie diet, three very low-calorie diet, one prolonged fasting). Thirteen studies examined neurotransmitter systems (six used tracers for dopamine DRD2/3 receptors: two each for ¹¹ C-raclopride, ¹⁸ F-fallypride, ¹²³ I-IBZM; one for dopamine transporter, ¹²³ I-FP-CIT; one used tracer for serotonin 5-HT_2A receptor, ¹⁸ F-altanserin; two used tracer

SUBMITTER: Al-Alsheikh AS 

PROVIDER: S-EPMC10909448 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature