The role of online MR-guided multi-fraction stereotactic ablative radiotherapy in lung tumours.

ABSTRACT:

Background

The aim of this prospective observational study was to evaluate the dosimetry benefits, changes in pulmonary function, and clinical outcome of online adaptive MR-guided SBRT.

Methods

From 11/2020-07/2022, 45 consecutive patients with 59 lesions underwent multi-fraction SBRT (3-8 fractions) at our institution. Patients were eligible if they had biopsy-proven NSCLC or lung cancer/metastases diagnosed via clinical imaging. Endpoints were local control (LC) and overall survival (OS). We evaluated PTV/GTV dose coverage, organs at risk exposure, and changes in pulmonary function (PF). Acute toxicity was classified per the National Cancer Institute-Common Terminology Criteria for Adverse Events version 5.0.

Results

The median PTV was 14.4 cm³ (range: 3.

SUBMITTER: Hering S 

PROVIDER: S-EPMC10909605 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature