Correlation of mitochondrial respiration in platelets, peripheral blood mononuclear cells and muscle fibers.

ABSTRACT: There is a growing interest for the possibility of using peripheral blood cells (including platelets) as markers for mitochondrial function in less accessible tissues. Only a few studies have examined the correlation between respiration in blood and muscle tissue, with small sample sizes and conflicting results. This study investigated the correlation of mitochondrial respiration within and across tissues. Additional analyses were performed to elucidate which blood cell type would be most useful for assessing systemic mitochondrial function. There was a significant but weak within tissue correlation between platelets and peripheral blood mononuclear cells (PBMCs). Neither PBMCs nor platelet respiration correlated significantly with muscle respiration. Muscle fibers from a group of athletes

SUBMITTER: Westerlund E 

PROVIDER: S-EPMC10909709 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature