Anhedonia and depression severity measures during ketamine administration in treatment-resistant depression.

ABSTRACT:

Background

Anhedonia is a core symptom of depression characterized by a diminished ability to experience pleasure. Currently available treatments for depression often fall short in adequately addressing anhedonia that often presents as a chronic and debilitating symptom. Ketamine is known to possess antianhedonic properties.

Methods

This post-hoc analysis of a naturalistic observational study of treatment-resistant depression inpatients (n=28) analyzed antianhedonic response patterns measured by Snaith-Hamilton Pleasure Scale and changes in Inventory of Depressive Symptomatology in responders (n=6) and non-responders (n=22) stratified per Montgomery-Åsberg Depression Rating Scale during short-term ketamine treatment.

Results

Results show that responders signifi

SUBMITTER: Kwasny A 

PROVIDER: S-EPMC10909946 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature