The impact of smoking and alcohol consumption on rosacea: a multivariable Mendelian randomization study.

ABSTRACT:

Backgrounds

Observational studies have shown that cigarette smoking is inversely associated with risk of rosacea, However, it remains uncertain whether this association is causal or it is a result of reverse causation, and whether this association is affected by drinking behaviors.

Methods

This study utilized the summary-level data from the largest genome-wide association study (GWAS) for smoking, alcohol consumption, and rosacea. The objective was to investigate the effect of genetically predicted exposures to smoking and alcohol consumption on the risk of developing rosacea. Two-sample bidirectional Mendelian randomization (MR) was applied, accompanied by sensitive analyses to validate the robustness of findings. Furthermore, multivariable MR was conducted to evaluate the

SUBMITTER: Chu Z 

PROVIDER: S-EPMC10909955 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature