Serum exosomal microRNA pathway activation in placenta accreta spectrum: pathophysiology and detection.

ABSTRACT:

Background

Placenta accreta spectrum disorders are a complex range of placental pathologies that are associated with significant maternal morbidity and mortality. A diagnosis of placenta accreta spectrum relies on ultrasonographic findings with modest positive predictive value. Exosomal microRNAs are small RNA molecules that reflect the cellular processes of the origin tissues.

Objective

We aimed to explore exosomal microRNA expression to understand placenta accreta spectrum pathology and clinical use for placenta accreta spectrum detection.

Study design

This study was a biomarker analysis of prospectively collected samples at 2 academic institutions from 2011 to 2022. Plasma specimens were collected from patients with suspected placenta accreta spectrum, placenta pre

SUBMITTER: Munoz JL 

PROVIDER: S-EPMC10910333 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature