Molecular Epidemiology of Omicron CH.1.1 Lineage: Genomic and Phenotypic Data Perspective.

ABSTRACT:

Background

The Omicron variant (B.1.1.529 lineage) of SARS-CoV-2 represents a substantial global health challenge due to its high transmissibility and potential resistance to immunity from vaccines or previous infections. Among the rapidly evolving Omicron lineages, the BA.2.75 and the emerging CH.1.1 have garnered attention. While BA.2.75 is marked by mutations that may enhance immune evasion, CH.1.1 is distinguished by the S: L452R mutation, linked to increased pathogenicity and transmission. Initially identified in India by the end of 2021, these variants have exhibited global dissemination, signaling an urgent need to track and analyze their progression.

Methods

In this study, the genomic and geographical distribution data of CH.1.1 were collected from the Global Initiat

SUBMITTER: Al Qurashi YMA 

PROVIDER: S-EPMC10910519 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature