Spectral Dependence of Light Exposure on Retinal Pigment Epithelium Disruption in Living Primate Retina.

ABSTRACT:

Purpose

RPE disruption with light exposures below or close to the American National Standards Institute (ANSI) photochemical maximum permissible exposure (MPE) have been observed, but these findings were limited to two wavelengths. We have extended the measurements across the visible spectrum.

Methods

Retinal imaging with fluorescence adaptive optics scanning light ophthalmoscopy (FAOSLO) was used to provide an in vivo measure of RPE disruption at a cellular level. The threshold retinal radiant exposures (RREs) for RPE disruption (localized detectable change in the fluorescence image) were determined at 460, 476, 488, 530, 543, 561, 594, 632, and 671 nm (uniform 0.5° square exposure) using multiples locations in 4 macaques.

Results

FAOSLO is sensitive in detecting RPE

SUBMITTER: Zhang J 

PROVIDER: S-EPMC10910637 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature