Multiple treatments with human embryonic stem cell-derived mesenchymal progenitor cells preserved the fertility and ovarian function of perimenopausal mice undergoing natural aging.

ABSTRACT:

Objectives

Currently, no approved stem cell-based therapies for preserving ovarian function during aging. To solve this problem, we developed a long-term treatment for human embryonic stem cell-derived mesenchymal progenitor cells (hESC-MPCs). We investigated whether the cells retained their ability to resist ovarian aging, which leads to delayed reproductive senescence.

Materials and methods

In a middle-aged female model undergoing natural aging, we analyzed whether hESC-MPCs benefit the long-term maintenance of reproductive fecundity and ovarian reservoirs and how their transplantation regulates ovarian function.

Results

The number of primordial follicles and mice with regular estrous cycles were increased in perimenopausal mice who underwent multiple introductions

SUBMITTER: Shin EY 

PROVIDER: S-EPMC10910829 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature