Genetic and biomarker modulation of arterial stiffness change in the SardiNIA population cohort.

ABSTRACT:

Background and aims

Arterial stiffness (AS), quantified by pulse wave velocity (PWV), arises due to impaired arterial elastic tissue and smooth muscle dysfunction. We aimed to examine the longitudinal association of genetic, lipid and inflammation biomarkers with PWV and how these associations may change with aging.

Materials and methods

We utilized genotype and four time-point biomarker data from the SardiNIA cohort [n = 6,301; mean baseline age 43.3 (SD 17.3); 58% females]. To investigate the association of PWV with genetic variants, lipid, and inflammation biomarkers, we employed linear mixed modeling, using age as the time scale. Biomarkers exhibiting significant longitudinal associations were categorized into tertiles and individuals within the second tertile or

SUBMITTER: Asefa NG 

PROVIDER: S-EPMC10910914 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature