Fluorescence guided surgery imaging systems for breast cancer identification: a systematic review.

ABSTRACT:

Significance

Breast-conserving surgery (BCS) is limited by high rates of positive margins and re-operative interventions. Fluorescence-guided surgery seeks to detect the entire lesion in real time, thus guiding the surgeons to remove all the tumor at the index procedure.

Aim

Our aim was to identify the optimal combination of a camera system and fluorophore for fluorescence-guided BCS.

Approach

A systematic review of medical databases using the terms "fluorescence," "breast cancer," "surgery," and "fluorescence imaging" was performed. Cameras were compared using the ratio between the fluorescent signal from the tumor compared to background fluorescence, as well as diagnostic accuracy measures, such as sensitivity, specificity, and positive predictive value.

Results<

SUBMITTER: Kedrzycki MS 

PROVIDER: S-EPMC10911048 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature