Modeling infection from SARS-CoV-2 wastewater concentrations: promise, limitations, and future directions.

ABSTRACT: Estimating total infection levels, including unreported and asymptomatic infections, is important for understanding community disease transmission. Wastewater can provide a pooled community sample to estimate total infections that is independent of case reporting biases toward individuals with moderate to severe symptoms and by test-seeking behavior and access. We derive three mechanistic models for estimating community infection levels from wastewater measurements based on a description of the processes that generate SARS-CoV-2 RNA signals in wastewater and accounting for the fecal strength of wastewater through endogenous microbial markers, daily flow, and per-capita wastewater generation estimates. The models are illustrated through two case studies of wastewater data collected during 2

SUBMITTER: Soller J 

PROVIDER: S-EPMC10911093 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature