Pre-pregnancy body mass index and gut microbiota of mothers and children 5 years postpartum.

ABSTRACT:

Background

Maternal pre-pregnancy body mass index (BMI) has been linked to altered gut microbiota in women shortly after delivery and in their offspring in the first few years of life. But little is known about how long these differences persist.

Methods

We followed 180 mothers and children from pregnancy until 5-year postpartum in the Gen3G cohort (Canada, enrolled 2010-2013). At 5 years postpartum we collected stool samples from mothers and children and estimated the gut microbiota by 16 S rRNA sequencing (V4 region) using Illumina MiSeq, and assigning amplicon sequence variants (ASV). We examined whether overall microbiota composition (as measured by microbiota β diversity) was more similar between mother-child pairs compared to between mothers or between children. We als

SUBMITTER: Liu T 

PROVIDER: S-EPMC10911130 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature