Disparity of serum uric acid threshold for CKD among hypertensive and non-hypertensive individuals.

ABSTRACT:

Introduction

Hypertension and rising serum uric acid (sUA) played a pivotal role in the development of Chronic Kidney Disease (CKD). This study investigates the interactive effect of sUA and hypertension on CKD and identifies the optimal threshold of sUA among individuals with and without hypertension in the Chinese community population.

Materials and methods

The study included 4180 individuals aged 45-85 years, derived from the China Health and Retirement Longitudinal Study (CHARLS) between 2011 and 2015. Additionally, a hospital-based study enrolled subjects in the Department of Nephrology at Zhongshan Hospital, China from January 1, 2019, to December 31, 2021. The interaction effect analysis were used to assess the impact of sUA and hypertension on CKD. We also compared t

SUBMITTER: Zhu B 

PROVIDER: S-EPMC10911134 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature