Identification of gut microbes-related molecular subtypes and their biomarkers in colorectal cancer.

ABSTRACT: The role of gut microbes (GM) and their metabolites in colorectal cancer (CRC) development has attracted increasing attention. Several studies have identified specific microorganisms that are closely associated with CRC occurrence and progression, as well as key genes associated with gut microorganisms. However, the extent to which gut microbes-related genes can serve as biomarkers for CRC progression or prognosis is still poorly understood. This study used a bioinformatics-based approach to synthetically analyze the large amount of available data stored in The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Through this analysis, this study identified two distinct CRC molecular subtypes associated with GM, as well as CRC markers related to GM. In addition, these ne

SUBMITTER: Liu X 

PROVIDER: S-EPMC10911361 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature