Identification of an angiogenesis-related risk score model for survival prediction and immunosubtype screening in multiple myeloma.

ABSTRACT:

Background

Multiple myeloma (MM) is an incurable B-cell malignancy, but with the emergence of immunotherapy, a potential cure is hopeful. The individualized interaction between the tumor and bone marrow (BM) microenvironment determines the response to immunotherapy. Angiogenesis is a constant hallmark of the BM microenvironment in MM. However, little is known about the potency ability of angiogenesis-associated genes (AAGs) to regulate the immune microenvironment of MM patients.

Methods

We comprehensively dissected the associations between angiogenesis and genomic landscapes, prognosis, and the immune microenvironment by integrating 36 AAGs. Immunohistochemistry was performed to verify the correlation between angiogenic factor expression and patient prognosis. Single-sample

SUBMITTER: Yu M 

PROVIDER: S-EPMC10911366 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature