Identification of an immune-related eRNA prognostic signature for clear cell renal cell carcinoma.

ABSTRACT:

Background

Immune-related enhancer RNAs (eRNAs) have garnered significant attention in cancer metabolism research, yet their specific roles in ccRCC have remained elusive.

Methods

We retrieved eRNA expression profiles from TCGA database and identified immune-related eRNAs (IREs) by assessing their co-expression with immune genes. Utilizing consensus clustering, we organized these IREs into two distinct clusters. The construction of an IREs signature was accomplished through the LASSO and multivariate Cox analysis. Furthermore, we performed Cell Counting Kit-8 and clonogenic assays to assess changes in the proliferative capacity of Caki-1 and 769-P cells.

Results

The existence of two clusters of immune-related eRNAs in ccRCC, each with distinctive prognostic and immuno

SUBMITTER: Lv Y 

PROVIDER: S-EPMC10911372 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature