Unexpected expansion of the voltage-gated proton channel family.

ABSTRACT: Voltage-gated ion channels, whose first identified function was to generate action potentials, are divided into subfamilies with numerous members. The family of voltage-gated proton channels (H_V ) is tiny. To date, all species found to express H_V have exclusively one gene that codes for this unique ion channel. Here we report the discovery and characterization of three proton channel genes in the classical model system of neural plasticity, Aplysia californica. The three channels (AcH_V 1, AcH_V 2, and AcH_V 3) are distributed throughout the whole animal. Patch-clamp analysis confirmed proton selectivity of these channels but they all differed markedly in gating. AcH_V 1 gating resembled H_V in mammalian cells where it

SUBMITTER: Chaves G 

PROVIDER: S-EPMC10911540 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature