Metformin, Cognitive Function, and Changes in the Gut Microbiome.

ABSTRACT: The decline in cognitive function and the prevalence of neurodegenerative disorders are among the most serious threats to health in old age. The prevalence of dementia has reached 50 million people worldwide and has become a major public health problem. The causes of age-related cognitive impairment are multiple, complex, and difficult to determine. However, type 2 diabetes (T2D) is linked to an enhanced risk of cognitive impairment and dementia. Human studies have shown that patients with T2D exhibit dysbiosis of the gut microbiota. This dysbiosis may contribute to the development of insulin resistance and increased plasma lipopolysaccharide concentrations. Metformin medication mimics some of the benefits of calorie restriction and physical activity, such as greater insulin sensitivity an

SUBMITTER: Rosell-Diaz M 

PROVIDER: S-EPMC10911951 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature