Protective Factors and the Pathogenesis of Complications in Diabetes.

ABSTRACT: Chronic complications of diabetes are due to myriad disorders of numerous metabolic pathways that are responsible for most of the morbidity and mortality associated with the disease. Traditionally, diabetes complications are divided into those of microvascular and macrovascular origin. We suggest revising this antiquated classification into diabetes complications of vascular, parenchymal, and hybrid (both vascular and parenchymal) tissue origin, since the profile of diabetes complications ranges from those involving only vascular tissues to those involving mostly parenchymal organs. A major paradigm shift has occurred in recent years regarding the pathogenesis of diabetes complications, in which the focus has shifted from studies on risks to those on the interplay between risk and protecti

SUBMITTER: Yu MG 

PROVIDER: S-EPMC10911956 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature