The secretome of macrophages has a differential impact on spinal cord injury recovery according to the polarization protocol.

ABSTRACT:

Introduction

The inflammatory response after spinal cord injury (SCI) is an important contributor to secondary damage. Infiltrating macrophages can acquire a spectrum of activation states, however, the microenvironment at the SCI site favors macrophage polarization into a pro-inflammatory phenotype, which is one of the reasons why macrophage transplantation has failed.

Methods

In this study, we investigated the therapeutic potential of the macrophage secretome for SCI recovery. We investigated the effect of the secretome in vitro using peripheral and CNS-derived neurons and human neural stem cells. Moreover, we perform a pre-clinical trial using a SCI compression mice model and analyzed the recovery of motor, sensory and autonomic functions. Instead of transplanting the cell

SUBMITTER: Lentilhas-Graca J 

PROVIDER: S-EPMC10912310 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature