Unlocking hidden potential: advancements, approaches, and obstacles in repurposing drugs for cancer therapy.

ABSTRACT: High rates of failure, exorbitant costs, and the sluggish pace of new drug discovery and development have led to a growing interest in repurposing "old" drugs to treat both common and rare diseases, particularly cancer. Cancer, a complex and heterogeneous disease, often necessitates a combination of different treatment modalities to achieve optimal outcomes. The intrinsic polygenicity of cancer, intricate biological signalling networks, and feedback loops make the inhibition of a single target frequently insufficient for achieving the desired therapeutic impact. As a result, addressing these complex or "smart" malignancies demands equally sophisticated treatment strategies. Combinatory treatments that target the multifaceted oncogenic signalling network hold immense promise. Repurposed dru

SUBMITTER: Weth FR 

PROVIDER: S-EPMC10912636 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature