Subjective feelings associated with expectations and rewards during risky decision-making in impulse control disorder.

ABSTRACT: Impulse Control Disorder (ICD) in Parkinson's disease is a behavioral addiction induced by dopaminergic therapies, but otherwise unclear etiology. The current study investigates the interaction of reward processing variables, dopaminergic therapy, and risky decision-making and subjective feelings in patients with versus without ICD. Patients with (n = 18) and without (n = 12) ICD performed a risky decision-making task both 'on' and 'off' standard-of-care dopaminergic therapies (the task was performed on 2 different days with the order of on and off visits randomized for each patient). During each trial of the task, participants choose between two options, a gamble or a certain reward, and reported how they felt about decision outcomes. Subjective feelings of 'pleasure' are differentially d

SUBMITTER: Liebenow B 

PROVIDER: S-EPMC10912783 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature