Delivery and short-term maternal and fetal safety of vaginally administered PEG-PLGA nanoparticles.

ABSTRACT: At the onset of pregnancy, people with preexisting conditions face additional challenges in carrying their pregnancy to term, as the safety of the developing fetus and pregnant person is a significant factor of concern. Nanoparticle (NP)-based therapies have displayed success against various conditions and diseases in non-pregnant patients, but the use of NPs in maternal-fetal health applications needs to be better established. Local vaginal delivery of NPs is a promising administration route with the potential to yield high cargo retention in the vagina and improved therapeutic efficacy compared to systemic administration that results in rapid NP clearance by the hepatic first-pass effect. In this study, we investigated the biodistribution and short-term toxicity of poly(ethylene glycol)-

SUBMITTER: Irvin-Choy NS 

PROVIDER: S-EPMC10913101 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature