The RdRp genotyping of SARS-CoV-2 isolated from patients with different clinical spectrum of COVID-19.

ABSTRACT:

Background

The evolution of SARS-CoV-2 has been observed from the very beginning of the fight against COVID-19, some mutations are indicators of potentially dangerous variants of the virus. However, there is no clear association between the genetic variants of SARS-CoV-2 and the severity of COVID-19. We aimed to analyze the genetic variability of RdRp in correlation with different courses of COVID-19.

Results

The prospective study included 77 samples of SARS-CoV-2 isolated from outpatients (1st degree of severity) and hospitalized patients (2nd, 3rd and 4th degree of severity). The retrospective analyses included 15,898,266 cases of SARS-CoV-2 genome sequences deposited in the GISAID repository. Single-nucleotide variants were identified based on the four sequenced amplified

SUBMITTER: Majchrzak M 

PROVIDER: S-EPMC10913261 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature