Causal effects of gut microbiome on HIV infection: a two-sample mendelian randomization analysis.

ABSTRACT:

Background

The causal association between gut microbiome and HIV infection remains to be elucidated. We conducted a two-sample mendelian randomization analysis to estimate the causality between gut microbiome and HIV infection.

Methods

Publicly released genome-wide association studies summary data were collected to perform the mendelian analysis. The GWAS summary data of gut microbiome was retrieved from the MiBioGen consortium, which contains 18 340 samples from 24 cohorts. GWAS summary data of HIV infection was collected from the R5 release of FinnGen consortium, including 357 HIV infected cases and 218 435 controls. The SNPs were selected as instrumental variables according to our selection rules. And SNPs with a F-statistics less than ten were regarded as weak instrument

SUBMITTER: Li K 

PROVIDER: S-EPMC10913272 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature