Untargeted metabolomic profiling reveals molecular signatures associated with type 2 diabetes in Nigerians.

ABSTRACT:

Background

Type 2 diabetes (T2D) has reached epidemic proportions globally, including in Africa. However, molecular studies to understand the pathophysiology of T2D remain scarce outside Europe and North America. The aims of this study are to use an untargeted metabolomics approach to identify: (a) metabolites that are differentially expressed between individuals with and without T2D and (b) a metabolic signature associated with T2D in a population of Sub-Saharan Africa (SSA).

Methods

A total of 580 adult Nigerians from the Africa America Diabetes Mellitus (AADM) study were studied. The discovery study included 310 individuals (210 without T2D, 100 with T2D). Metabolites in plasma were assessed by reverse phase, ultra-performance liquid chromatography and mass spectrometry (

SUBMITTER: Doumatey AP 

PROVIDER: S-EPMC10913364 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature