A rationally designed antimicrobial peptide from structural and functional insights of Clostridioides difficile translation initiation factor 1.

ABSTRACT: A significant increase of hospital-acquired bacterial infections during the COVID-19 pandemic has become an urgent medical problem. Clostridioides difficile is an urgent antibiotic-resistant bacterial pathogen and a leading causative agent of nosocomial infections. The increasing recurrence of C. difficile infection and antibiotic resistance in C. difficile has led to an unmet need for the discovery of new compounds distinctly different from present antimicrobials, while antimicrobial peptides as promising alternatives to conventional antibiotics have attracted growing interest recently. Protein synthesis is an essential metabolic process in all bacteria and a validated antibiotic target. Initiation factor 1 from C. difficile (Cd-IF1) is the smallest of the thre

SUBMITTER: Alanis E 

PROVIDER: S-EPMC10913371 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature