Dataset Information

Hypertension combined with limitations in activities of daily living and the risk for cardiovascular disease.

ABSTRACT:

Objective

The aim of present study was to evaluate the combined effect of hypertension and activities of daily living (ADL)/instrumental activities of daily living (IADL) with the risk of CVD, stroke and cardiac events.

Methods

A total of 14,083 participants aged 45 years or older from the China Health and Retirement longitudinal study were included in current study. Participants were divided into 4 groups according to hypertension and ADL/IADL status. Cox proportional hazards regression model was used to explore the associations between hypertension, ADL/IADL and new-onset CVD, stroke and cardiac events.

Results

During the 7-year follow-up, a total of 2,324 respondents experienced CVD (including 783 stroke and 1,740 cardiac events). Individuals with limitations in ADL alone, or with hypertension alone, or with both limitations in ADL and hypertension were associated with increased risk of CVD, with the adjusted hazard ratios (95% confidence intervals) were 1.17(1.00-1.35), 1.36(1.24-1.49) and 1.44(1.23-1.68), respectively. Those with limitations in ADL and hypertension also had higher risk of stroke (hazard ratios = 1.64; 1.26-2.14) and cardiac events (hazard ratios = 1.37; 1.14-1.64). Similarly, individuals with both limitations in IADL and hypertension were associated with increased risk of CVD (hazard ratios = 1.34; 1.15-1.57), stroke (hazard ratios = 1.50; 1.17-1.95) and cardiac events (hazard ratios = 1.27; 1.06-1.53).

Conclusion

Hypertension and limitations in ADL/IADL jointly increased the risk of CVD, stroke and cardiac events.

SUBMITTER: Li Y

PROVIDER: S-EPMC10913420 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Hypertension combined with limitations in activities of daily living and the risk for cardiovascular disease.

Li Yiqun Y Jiang Minglan M Ren Xiao X Han Longyang L Zheng Xiaowei X Wu Wenyan W

BMC geriatrics 20240304 1

<h4>Objective</h4>The aim of present study was to evaluate the combined effect of hypertension and activities of daily living (ADL)/instrumental activities of daily living (IADL) with the risk of CVD, stroke and cardiac events.<h4>Methods</h4>A total of 14,083 participants aged 45 years or older from the China Health and Retirement longitudinal study were included in current study. Participants were divided into 4 groups according to hypertension and ADL/IADL status. Cox proportional hazards reg ...[more]

PMID: 38439007

Similar Datasets

Project description:BackgroundSarcopenia is characterized by loss of muscle mass and function and is known to impair activities of daily living (ADL) in community-dwelling elderly people. However, the impact of sarcopenia on ADL in patients with interstitial lung disease (ILD) remains unclear. This study aimed to determine the relationship between sarcopenia and ADL in ILD patients and to identify sarcopenia components that contribute to these impairments.MethodsThis cross-sectional study included 50 patients (median age 76 years) with stable ILD who were hospitalized at Hyogo Medical University Hospital between June 2022 and February 2024. Sarcopenia was diagnosed using the Asian Working Group for Sarcopenia 2019 criteria. Basic ADL were evaluated using the Barthel Index (BI), and the impact of dyspnea on ADL was assessed using the Barthel Index-dyspnea (BI-d). Clinical assessments included the 6-min walk test, the Hospital Anxiety and Depression Scale score, and the EuroQol-5 Dimensions-5 Levels tool. Statistical analyses were performed to compare outcomes between patients with and without sarcopenia and to identify factors affecting BI and BI-d scores.ResultsSarcopenia was diagnosed in 21 patients (42%). The BI score was significantly lower (85 vs. 90, P<0.01) and the BI-d score was significantly higher (45 vs. 10, P<0.01) in the sarcopenia group. The sarcopenia group also had a shorter 6-min walk distance (245.0 vs. 318.5 m, P=0.03), a higher score for the depression component of the Hospital Anxiety and Depression Scale (6.0 vs. 5.0, P=0.02), and a lower EuroQol-5 Dimensions-5 Levels score (0.58 vs. 0.84, P<0.01). Multiple linear regression analyses showed a significant association of sarcopenia with a lower BI score (β=-0.30, P=0.03) and a higher BI-d score (β=0.45, P<0.01). The skeletal muscle mass index (SMI) was the only component of sarcopenia that had a significant association with the BI score, and gait speed was associated with the BI-d score in both men and women.ConclusionsSarcopenia was significantly associated with greater impairment of basic ADL and limitation of ADL by dyspnea in patients with ILD. SMI and gait speed are components of sarcopenia that affect these outcomes. Targeted interventions are needed to improve ADL and quality of life in these patients.

Project description:BackgroundLimitations in instrumental activities of daily living (IADL) hinder a person's ability to live independently in the community and self-manage their conditions, but its impact on hospital readmission has not been firmly established.ObjectiveTo test the importance of IADL dependency as a predictor of 30-day readmissions and quantify its impact relative to other morbidities.DesignA retrospective cohort study of the population-based Health and Retirement Study linked to Medicare claims data. Random forest was used to rank each predictor variable in terms of its ability to predict readmission. Classification and regression tree (CART) was used to identify complex multimorbidity combinations associated with high or low risk of readmission. Generalized linear regression was used to estimate the adjusted relative risk of readmission for IADL limitations.SubjectsHospitalizations of adults age 65 and older (n = 20,007), from 6617 unique subjects.Main measuresThe main outcome was 30-day all-cause unplanned readmission. The main predictor of interest was self-reported IADL limitation. Other key predictors were self-reported complex multimorbidity including chronic diseases, geriatric syndromes, and activities of daily living (ADL) limitations, along with demographic, socioeconomic, and behavioral factors.Key resultsThe overall 30-day readmission rate in the study was 16.4%. Random forest analysis ranked ADLs and IADL limitations as the two most important predictors of 30-day readmission. CART identified hospitalizations of patients with IADL limitations and diabetes as a subgroup at the highest risk of readmission (26% readmitted). Multivariable regression analyses showed that ADL limitations were associated with 1.17 (1.06-1.29) times higher risk of readmission even after adjusting for other patient covariates. Risk prediction was modest though for even the best model (AUC = 0.612).ConclusionsIADL limitations are key predictors of 30-day readmission as demonstrated using several machine learning methods. Routine assessment of functional abilities in hospital settings could help identify those most at risk.

Dataset Information

Hypertension combined with limitations in activities of daily living and the risk for cardiovascular disease.

Objective

Methods

Results

Conclusion

Publications

Hypertension combined with limitations in activities of daily living and the risk for cardiovascular disease.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets