A causal relationship between panic disorder and risk of alzheimer disease: a two-sample mendelian randomization analysis.

ABSTRACT:

Background

Observational studies have suggested a link between panic disorder (PD) and Alzheimer disease (AD). This study aimed to identify the underlying association of PD with the risk of AD using Mendelian randomization.

Methods

Genetic instrumental variables (IVs) were retrieved in the genome-wide association study between PD and AD. Then, five different models, namely inverse variance weighting (IVW), weighted median, weighted mode, MR-Egger and MR-robust adjusted profile scores (MR-RAPS), were used for MR Analysis. Finally, the heterogeneity and pleiotropy of identified IVs were verified by multiple sensitivity tests.

Results

The Cochran's Q test based on MR Egger and IVW showed that no evidence of heterogeneity was found in the effects of instrumental variables

SUBMITTER: Tian Y 

PROVIDER: S-EPMC10913557 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature