Bile acid profiling as an effective biomarker for staging in pediatric inflammatory bowel disease.

ABSTRACT: Rapid and accurate clinical staging of pediatric patients with inflammatory bowel disease (IBD) is crucial to determine the appropriate therapeutic approach. This study aimed to identify effective, convenient biomarkers for staging IBD in pediatric patients. We recruited cohorts of pediatric patients with varying severities of IBD to compare the features of the intestinal microbiota and metabolites between the active and remitting disease stages. Metabolites with potential for staging were targeted for further assessment in both patients and colitis model mice. The performance of these markers was determined using machine learning and was validated in a separate patient cohort. Pediatric patients with IBD exhibited distinct gut microbiota structures at different stages of disease activity.

SUBMITTER: Chen W 

PROVIDER: S-EPMC10913721 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature