IL-22 Binding Protein Controls IL-22-Driven Bleomycin-Induced Lung Injury.

ABSTRACT: The high mortality rates of acute lung injury and acute respiratory distress syndrome challenge the field to identify biomarkers and factors that can be exploited for therapeutic approaches. IL-22 is a cytokine that has antibacterial and reparative properties in the lung. However, it also can exacerbate inflammation and requires tight control by the extracellular inhibitory protein known as IL-22 binding protein (IL-22BP) (Il22ra2). This study showed the necessity of IL-22BP in controlling and preventing acute lung injury using IL-22BP knockout mice (Il22ra2^-/-) in the bleomycin model of acute lung injury/acute respiratory distress syndrome. Il22ra2^-/- mice had greater sensitivity (weight loss and death) and pulmonary inflammation in the acute phase (first 7 days) of

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC10913761 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature