Insights into the cell fate decision-making processes from chromosome structural reorganizations.

ABSTRACT: The cell fate decision-making process, which provides the capability of a cell transition to a new cell type, involves the reorganizations of 3D genome structures. Currently, the high temporal resolution picture of how the chromosome structural rearrangements occur and further influence the gene activities during the cell-state transition is still challenging to acquire. Here, we study the chromosome structural reorganizations during the cell-state transitions among the pluripotent embryonic stem cell, the terminally differentiated normal cell, and the cancer cell using a nonequilibrium landscape-switching model implemented in the molecular dynamics simulation. We quantify the chromosome (de)compaction pathways during the cell-state transitions and find that the two pathways having the sam

SUBMITTER: Chu X 

PROVIDER: S-EPMC10914134 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature