Age-dependent ventilator-induced lung injury: Mathematical modeling, experimental data, and statistical analysis.

ABSTRACT: A variety of pulmonary insults can prompt the need for life-saving mechanical ventilation; however, misuse, prolonged use, or an excessive inflammatory response, can result in ventilator-induced lung injury. Past research has observed an increased instance of respiratory distress in older patients and differences in the inflammatory response. To address this, we performed high pressure ventilation on young (2-3 months) and old (20-25 months) mice for 2 hours and collected data for macrophage phenotypes and lung tissue integrity. Large differences in macrophage activation at baseline and airspace enlargement after ventilation were observed in the old mice. The experimental data was used to determine plausible trajectories for a mathematical model of the inflammatory response to lung injury

SUBMITTER: Hay Q 

PROVIDER: S-EPMC10914268 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature