Shared and distinct structural brain networks related to childhood maltreatment and social support: connectome-based predictive modeling.

ABSTRACT: Childhood maltreatment (CM) has been associated with changes in structural brain connectivity even in the absence of mental illness. Social support, an important protective factor in the presence of childhood maltreatment, has been positively linked to white matter integrity. However, the shared effects of current social support and CM and their association with structural connectivity remain to be investigated. They might shed new light on the neurobiological basis of the protective mechanism of social support. Using connectome-based predictive modeling (CPM), we analyzed structural connectomes of N = 904 healthy adults derived from diffusion-weighted imaging. CPM predicts phenotypes from structural connectivity through a cross-validation scheme. Distinct and shared networks of white matt

SUBMITTER: Winter A 

PROVIDER: S-EPMC10914611 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature