Functional genomic mechanisms of opioid action and opioid use disorder: a systematic review of animal models and human studies.

ABSTRACT: In the past two decades, over-prescription of opioids for pain management has driven a steep increase in opioid use disorder (OUD) and death by overdose, exerting a dramatic toll on western countries. OUD is a chronic relapsing disease associated with a lifetime struggle to control drug consumption, suggesting that opioids trigger long-lasting brain adaptations, notably through functional genomic and epigenomic mechanisms. Current understanding of these processes, however, remain scarce, and have not been previously reviewed systematically. To do so, the goal of the present work was to synthesize current knowledge on genome-wide transcriptomic and epigenetic mechanisms of opioid action, in primate and rodent species. Using a prospectively registered methodology, comprehensive literature se

SUBMITTER: Falconnier C 

PROVIDER: S-EPMC10914629 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature