Oxygen-enhanced MRI assessment of tumour hypoxia in head and neck cancer is feasible and well tolerated in the clinical setting.

ABSTRACT:

Background

Tumour hypoxia is a recognised cause of radiotherapy treatment resistance in head and neck squamous cell carcinoma (HNSCC). Current positron emission tomography-based hypoxia imaging techniques are not routinely available in many centres. We investigated if an alternative technique called oxygen-enhanced magnetic resonance imaging (OE-MRI) could be performed in HNSCC.

Methods

A volumetric OE-MRI protocol for dynamic T1 relaxation time mapping was implemented on 1.5-T clinical scanners. Participants were scanned breathing room air and during high-flow oxygen administration. Oxygen-induced changes in T1 times (ΔT1) and R₂* rates (ΔR₂*) were measured in malignant tissue and healthy organs. Unequal variance t-test was used. Patients were surveyed

SUBMITTER: McCabe A 

PROVIDER: S-EPMC10914657 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature