Unveiling NUSAP1 as a common gene signature linking chronic HBV infection and HBV-related HCC.

ABSTRACT:

Background

Hepatitis B virus (HBV) is a significant contributor to the development of hepatocellular carcinoma (HCC). Chronic HBV infection (CHB) facilitates disease progression through various mechanisms. However, the specific factor responsible for the progression of HBV infection to HCC remains unresolved. This study aims to identify the hub gene linking CHB and HBV-related HCC through bioinformatic analysis and experimental verification.

Methods

Differentially expressed genes (DEGs) were identified in datasets encompassing CHB and HBV-HCC patients from the GEO database. Enriched pathways were derived from GO and KEGG analysis. Hub genes were screened by protein-protein interaction (PPI) analysis and different modules in Cytoscape software. The significance of the selecte

SUBMITTER: Meng J 

PROVIDER: S-EPMC10914659 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature