Longitudinal metabolite profiling of Streptococcus pneumoniae-associated community-acquired pneumonia.

ABSTRACT:

Introduction

Longitudinal biomarkers in patients with community-acquired pneumonia (CAP) may help in monitoring of disease progression and treatment response. The metabolic host response could be a potential source of such biomarkers since it closely associates with the current health status of the patient.

Objectives

In this study we performed longitudinal metabolite profiling in patients with CAP for a comprehensive range of metabolites to identify potential host response biomarkers.

Methods

Previously collected serum samples from CAP patients with confirmed Streptococcus pneumoniae infection (n = 25) were used. Samples were collected at multiple time points, up to 30 days after admission. A wide range of metabolites was measured, including amines, acylcarnitines, o

SUBMITTER: den Hartog I 

PROVIDER: S-EPMC10914916 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature