Lactiplantibacillusplantarum APsulloc331261 (GTB1^™) promotes butyrate production to suppress mucin hypersecretion in a murine allergic airway inflammation model.

ABSTRACT:

Introduction

Allergic airway diseases are one of the serious health problems in worldwide and allergic airway inflammation is a prerequisite led to the exacerbated situation such as mucus hypersecretion, epithelial barrier damage and microbiota dysbiosis. Because of side effects and low efficiencies of current therapeutics, the need for novel alternatives has been urged. Probiotics in which have diverse and beneficial modulatory effects have been applied to the airway inflammation model and the underlying mechanism needs to be investigated.

Methods

We aimed to evaluate whether our target strain, Lactiplantibacillus plantarum APsulloc331261 (GTB1TM) isolated from green tea, can ameliorate allergic airway inflammation in mice and to figure out the mechanism. We induced allergi

SUBMITTER: Kim HS 

PROVIDER: S-EPMC10915089 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature