Gene expression profiles of skin from cyclin dependent kinases 5-knockdown mice.

ABSTRACT:

Objective

This study aimed to identify genes regulated by cyclin dependent kinases 5 (CDK5) that participate in hair pigmentation in mice.

Methods

The mRNA expression profiles of skin samples from CDK5-knockdown mice were constructed using high-throughput RNA sequencing and compared with those of wild-type mice.

Results

In total, 8,002 known genes were differentially expressed between CDK5-knockdown and wild-type mice. Of these, 3,658 were upregulated and 4,344 were downregulated in the skin of CDK5-knockdown mice. An additional 318 previously unknown genes were also differentially expressed, with 171 downregulated and 147 upregulated genes in the skin of CDK5-knockdown mice. Of the known genes expressed in mouse skin, 80 were associated with hair color, with 61 showi

SUBMITTER: Yang S 

PROVIDER: S-EPMC10915219 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature