Integrated analysis of transcriptome and milk metagenome in subclinical mastitic and healthy cows.

ABSTRACT:

Objective

Abnormally increased somatic cell counts (SCCs) in milk is usually a sign of bovine subclinical mastitis. Mutual interaction between the host and its associated microbiota plays an important role in developing such diseases. The main objective of this study was to explore the difference between cows with elevated SCCs and healthy cattle from the perspective of host-microbe interplay.

Methods

A total of 31 milk samples and 23 bovine peripheral blood samples were collected from Holstein dairy cattle to conduct an integrated analysis of transcriptomic and metagenomics.

Results

The results showed that Ralstonia and Sphingomonas were enriched in cows with subclinical mastitis. The relative abundance of the two bacteria was positively correlated with the expressio

SUBMITTER: Zhang J 

PROVIDER: S-EPMC10915226 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature