CD39⁺ tumor infiltrating T cells from colorectal cancers exhibit dysfunctional phenotype.

ABSTRACT: Recent studies revealed that CD39 was highly expressed in tumor-specific CD4⁺ tumor infiltrating lymphocytes (TILs). However, the divergent function of CD39⁺ T cells remains to be elucidated in colorectal cancer (CRC). In this study, T cells from CRC patients and tumor-bearing mice were isolated to evaluate the function of CD39 in T cells. We found that CD39 was elevated in intratumoral T cells from CRC patients, and negatively correlated with cytokine secretion capacity. T cell activation induced CD39 expression, and CD39⁺ T cells produced more IFN-γ in response to CRC tumor antigens. In addition, CD39⁺ T cells in the spleens of tumor-bearing mice exhibited a stronger anti-tumor activity in vitro than CD39^- T cells, but there was no s

SUBMITTER: Feng Y 

PROVIDER: S-EPMC10915329 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature