Unknown

Dataset Information

0

Synthesis of pyrimido[4,5-b]quinolindiones and formylation: ultrasonically assisted reactions.

ABSTRACT: Ultrasound-assisted synthesis of pyrimido‌quinolindione derivatives via a multicomponent reaction and subsequent formylation with Vilsmeier-Haack reagent were performed. Compounds were prepared by a one-pot method from aminopyrimidinones, dimedone and aromatic aldehydes through a Mannich-type reaction sequence, and then functionalized under ultrasound irradiation and Vilsmeier-Haack conditions to give β-chlorovinylaldehyde products. Ultrasonically assisted reactions, experimental simplicity, good yields without using metallic catalysts and the control of hazardous material release are features of this simple procedure.

SUBMITTER: Trilleras J 

PROVIDER: S-EPMC10915537 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Synthesis of pyrimido[4,5-<i>b</i>]quinolindiones and formylation: ultrasonically assisted reactions.

Trilleras Jorge J   Charris-Molina Andrés A   Pérez-Gamboa Alfredo A   Acosta-Guzman Paola P   Quiroga Jairo J  

Royal Society open science 20240306 3

Ultrasound-assisted synthesis of pyrimido‌quinolindione derivatives via a multicomponent reaction and subsequent formylation with Vilsmeier-Haack reagent were performed. Compounds were prepared by a one-pot method from aminopyrimidinones, dimedone and aromatic aldehydes through a Mannich-type reaction sequence, and then functionalized under ultrasound irradiation and Vilsmeier-Haack conditions to give β-chlorovinylaldehyde products. Ultrasonically assisted reactions, experimental simplicity, goo  ...[more]

Similar Datasets

Unknown Microwave-assisted ring closure reactions: synthesis of 8-substituted xanthine derivatives and related pyrimido- and diazepinopurinediones.
| S-EPMC1698928 | biostudies-literature
Unknown Multicomponent synthesis of pyrimido[4,5-b] quinolines over a carbocationic catalytic system.
| S-EPMC10543543 | biostudies-literature
Unknown Sugar modified pyrimido[4,5-<i>b</i>]indole nucleosides: synthesis and antiviral activity.
| S-EPMC6084004 | biostudies-literature
Unknown Docking, Synthesis and Evaluation of the Antifungal Activity of Pyrimido [4,5-b]quinolins.
| S-EPMC7462489 | biostudies-literature
Unknown A novel synthesis of 3-(substituted)pyrimido[4,5-c]pyridazine-5,7(1H,6H)-diones.
| S-EPMC2987637 | biostudies-literature
Unknown One-pot synthesis of novel 1H-pyrimido[4,5-c][1,2]diazepines and pyrazolo[3,4-d]pyrimidines.
| S-EPMC1470455 | biostudies-literature
Unknown Design, Synthesis and Biological Evaluation of Novel Pyrimido[4,5-d]pyrimidine CDK2 Inhibitors as Anti-Tumor Agents.
| S-EPMC3163380 | biostudies-literature
Unknown Facile synthesis of novel acidic modified magnetic graphene oxide and its application in the green synthesis of pyrimido[4,5-b]quinolines.
| S-EPMC11402980 | biostudies-literature
Unknown 4,5,8a-Triphenyl-perhydro-pyrimido[4,5-d]pyrimidine-2,7-dione monohydrate.
| S-EPMC2979643 | biostudies-literature
Unknown Preparation of tetrasubstituted pyrimido[4,5-<i>d</i>]pyrimidine diones.
| S-EPMC4829973 | biostudies-literature