Abnormal characteristic static and dynamic functional network connectivity in idiopathic normal pressure hydrocephalus.

ABSTRACT:

Aims

Idiopathic Normal pressure hydrocephalus (iNPH) is a neurodegenerative disease characterized by gait disturbance, dementia, and urinary dysfunction. The neural network mechanisms underlying this phenomenon is currently unknown.

Methods

To investigate the resting-state functional connectivity (rs-FC) abnormalities of iNPH-related brain connectivity from static and dynamic perspectives and the correlation of these abnormalities with clinical symptoms before and 3-month after shunt. We investigated both static and dynamic functional network connectivity (sFNC and dFNC, respectively) in 33 iNPH patients and 23 healthy controls (HCs).

Results

The sFNC and dFNC of networks were generally decreased in iNPH patients. The reduction in sFNC within the default mode network

SUBMITTER: Huang W 

PROVIDER: S-EPMC10915979 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature